Abstract
A first systematic approach on new and simple preparation method of spherical granules in the system using organic granulating solution was carried out. Mixer granulation required narrow range of moisture content but gentle action of tumbling in the mixer and capillary forces were adequate to compact the porous mass and also were highly effective to produce granules close to sphere. Whereas the granules by massing and screening provided the more open structure, its pore distribution lied between 71 and 16 μm by above 50%, and on the contrary, that of the mixer granulated granules showed only below 25%. Increase in retention time in the mixer decreased the intragranular porosity of granules produced, and in comparison with granular particles produced by conventional wet granulation, those from the mixer granulation had the advantages of flow properties, packing characteristics and definite spherocity. They also had extremely low friability resulting in few fines.
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