Abstract
Insulin resistance (IR) is the principle etiological factor for development and progression of type-2 diabetes mellitus (T2DM) and decreased insulin function. Independently, increased serum uric acid (SUA) is known to play a critical role in the development of T2DM as well as in progression of its complications. To assess the correlation between SUA levels and IR in diabetic patients, data with lab investigations of HbA1c, fasting levels of serum glucose, UA, TAG, HDL-C of confirmed and known cases of T2DM were collected from the Hospital Biochemistry Laboratory, DMWIMS Hospital, Wayanad, Kerala. Fasting ratio of TAG to HDL-C was used as an index for IR. A significant increase in fasting serum glucose, SUA, HBA1C, TAG, TAG/HDL-C ratio (IR) and a significant decrease in HDL-C were observed in data of cases when compared with the data of normal healthy subjects. This study shows a positive correlation between SUA levels and IR in known cases of T2DM. Keywords type2 diabetes mellitus, serum uric acid, insulin resistance
Highlights
Insulin resistance (IR) is the principle etiological factor for development and progression of type-2 diabetes mellitus (T2DM) and decreased insulin function
Conflicting data exist about uric acid (UA) levels in T2DM, as low levels were found in diabetic patients, while elevated serum uric acid (SUA) is a feature of hyperinsulinemia and impaired glucose tolerance [2]
Study Parameters Data of fasting serum levels of glucose (FBS), uric acid (UA), Triacylglycerol (TAG), High density lipoprotein- Cholesterol (HDL-C) and Glycated Hb (HbA1c), of both type-2 diabetic and normal subjects were assessed for the present study
Summary
Insulin resistance (IR) is the principle etiological factor for development and progression of type-2 diabetes mellitus (T2DM) and decreased insulin function. Increased serum uric acid (SUA) is known to play a critical role in the development of T2DM as well as in progression of its complications [1]. Hyperuricemia is not always found in diabetic individuals. Conflicting data exist about UA levels in T2DM, as low levels were found in diabetic patients, while elevated SUA is a feature of hyperinsulinemia and impaired glucose tolerance [2]. The present study was undertaken to assess the correlation between SUA levels and IR in known cases of T2DM. Thweja et al / International Journal of Preclinical & Clinical Research 2021;2(2):
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