A Study on Mathematical Modelling of Michaelis–Menten Enzyme Kinetics Using Fractional Derivatives

Analyzing the Michaelis-Menten kinetics biochemical reaction model is essential in understanding enzyme-catalyzed reactions. Traditional models frequently fail to incorporate the complexities of fractional derivatives. This study employs the homotopy perturbation method (HPM) and the homotopy analysis method (HAM) to derive analytical expressions for enzyme, substrate, inhibitor, product, and other intermediate species concentrations. The methodologies include the application of fractional derivatives to improve the accuracy and adaptability of the model.The use of HPM and HAM in this context allows for a more comprehensive understanding of the biochemical reaction kinetics. The comparison of these two methodologies using numerical illustrations provides insights into their respective accuracies and applicability in biochemical modeling. Statistical analysis further strengthens the validation of these methods. Numerical examples demonstrate the effectiveness of HPM and HAM in dealing with the complexities associated with the Michaelis-Menten kinetics biochemical reaction model. The results highlight the improved precision in depicting the concentrations of various species within the reaction model. This study provides a comparison of the HAM findings with those produced by the HPM, demonstrating that the HAM approximate solutions are only valid for a short period, but the HPM results are very accurate and valid for a long time. This emphasizes the fact that the HPM applies to a wide range of nonlinear models and is reliable and promising when compared to other approaches. These approaches enhance the comprehension and application of biochemical reaction models, demonstrating efficacy through practical numerical results.

On Legendre polynomial approximation with the VIM or HAM for numerical treatment of nonlinear fractional differential equations

An analytic algorithm for the space–time fractional advection–dispersion equation

Rigid plate submerged in a Newtonian fluid and fractional differential equation problems via Caputo fractional derivative

In this paper, we present the approximate solutions of the time fractional chemical engineering equations by means of the variational iteration method (VIM) and homotopy perturbation method (HPM). The fractional derivatives are described in the Caputo sense. The solutions of the chemical reactor, reaction, and concentration equations are calculated in the form of convergent series with easily computable components. We compared the HPM against the VIM; an additional comparison will be made against the conventional numerical method. The results show that HPM is more promising, convenient, and efficient than VIM.

In this study, fractional Rosenau-Hynam equations is considered. We implement relatively new analytical techniques, the variational iteration method and the homotopy perturbation method, for solving this equation. The fractional derivatives are described in the Caputo sense. The two methods in applied mathematics can be used as alternative methods for obtaining analytic and approximate solutions for fractional Rosenau-Hynam equations. In these schemes, the solution takes the form of a convergent series with easily computable components. The present methods perform extremely well in terms of efficiency and simplicity.

In this paper, homotopy perturbation method (HPM) and variational iteration method (VIM) are used to solve the large amplitude torsional oscillations equations in a nonlinearly suspension bridge. This paper compares the HPM and VIM in order to solve the equations of nonlinearly suspension bridge. A comparative study between the HPM and VIM is presented in this work. The achieved results reveal that the HPM and VIM are very effective, convenient and quite accurate to nonlinear partial differential equations. These methods can be easily extended to other strongly nonlinear oscillations and can be found widely applicable in engineering and science. The Laplace transform method is applied to obtaining the Lagrange multiplier in the VIM solution.

The beam deformation equation has very wide applications in structural engineering. As a differential equation, it has its own problem concerning existence, uniqueness and methods of solutions. Often, original forms of governing differential equations used in engineering problems are simplified, and this process produces noise in the obtained answers. This paper deals with solution of second order of differential equation governing beam deformation using four analytical approximate methods, namely the Homotopy Perturbation Method (HPM), Variational Iteration Method (VIM) and Optimal Homotopy Asymptotic Method (OHAM). The comparisons of the results reveal that these methods are very effective, convenient and quite accurate to systems of non-linear differential equation.

This tutorial review of fractal-Cantorian spacetime and fractional calculus begins with Leibniz’s notation for derivative without limits which can be generalized to discontinuous media like fractal derivative and q-derivative of quantum calculus. Fractal spacetime is used to elucidate some basic properties of fractal which is the foundation of fractional calculus, and El Naschie’s mass-energy equation for the dark energy. The variational iteration method is used to introduce the definition of fractional derivatives. Fractal derivative is explained geometrically and q-derivative is motivated by quantum mechanics. Some effective analytical approaches to fractional differential equations, e.g., the variational iteration method, the homotopy perturbation method, the exp-function method, the fractional complex transform, and Yang-Laplace transform, are outlined and the main solution processes are given.

In this paper, an efficient modification of homotopy perturbation method, namely optimal homotopy perturbation method, is introduced for solving linear and nonlinear partial differential equations with large solution domain based on a new homotopy perturbation method and Pade approximation method. We compare the performance of the method with those of new homotopy perturbation and optimal variational iteration methods via three partial differential equations with large solution domain. Numerical results explicitly reveal that the suggested technique is highly capable to control the convergence region of approximate solution. Key words: New homotopy perturbation method, Pade´ approximation, optimal variational iteration method.

Based on He's variational iteration method idea, we modified the fractional variational iteration method and applied it to construct some approximate solutions of the generalized time-space fractional Schrödinger equation (GFNLS). The fractional derivatives are described in the sense of Caputo. With the help of symbolic computation, some approximate solutions and their iterative structure of the GFNLS are investigated. Furthermore, the approximate iterative series and numerical results show that the modified fractional variational iteration method is powerful, reliable, and effective when compared with some classic traditional methods such as homotopy analysis method, homotopy perturbation method, adomian decomposition method, and variational iteration method in searching for approximate solutions of the Schrödinger equations.

In this paper, the solution methodology of higher-order linear fractional partial deferential equations (FPDEs) as mentioned in eqs (1) and (2) below in Caputo definition relies on a new analytical method which is called the Laplace-residual power series method (L-RPSM). The main idea of our proposed technique is to convert the original FPDE in Laplace space, and then apply the residual power series method (RPSM) by using the concept of limit to obtain the solution. Some interesting and important numerical test applications are given and discussed to illustrate the procedure of our method, and also to confirm that this method is simple, understandable and very fast for obtaining the exact and approximate solutions (ASs) of FPDEs compared with other methods such as RPSM, variational iteration method (VIM), homotopy perturbation method (HPM) and Adomian decomposition method (ADM). The main advantage of the proposed method is its simplicity in computing the coefficients of terms of series solution by using only the concept of limit at infinity and not as the other well-known analytical method such as, RPSM that need to obtain the fractional derivative (FD) each time to determine the unknown coefficients in series solutions, and VIM, ADM, or HPM that need the integration operators which is difficult in fractional case.

Variational iteration method and homotopy perturbation method for fourth-order fractional integro-differential equations

This paper presents the concept of a new strategy that examines the analytical solution of the Harry Dym equation (HDEq) with fractional derivative in the Caputo sense. This new approach is called the Mohand homotopy perturbation transform scheme (MHPTS) which is constructed on the basis of the Mohand transform (MT) and the homotopy perturbation method (HPM). The implementation of MT produces the recurrence relation without any assumption and hypothesis theory whereas HPM is additionally used to overcome the nonlinearity in differential problems. Our primary focus is to handle the error analysis in the recurrence relation and generates the solution in the order of series. These obtained results yield the exact solution very rapidly due to its fast convergence. Some graphical representations are demonstrated to show the high efficiency and performance of this approach.

We suggest and analyze a technique by combining the variational iteration method and the homotopy perturbation method. This method is called the variational homotopy perturbation method. We use this method for solving Generalized Time-space Fractional Schrödinger equation. The fractional derivative is described in Caputo sense. The proposed scheme finds the solution without any discritization, transformation or restrictive assumptions. Several example is given to check the reliability and efficiency of the proposed technique.   Key words: Caputo derivative, variational iteration method, homotopy perturbation method, Schrödinger equation.