Abstract
Aim It was previously reported that the ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) can predict the clinical onset of preeclampsia. This study seeks to validate the association between ratios of sFlt-1/PlGF with preeclampsia and to identify the contribution of ethnicity across diverse populations of the Xinjiang Uygur Autonomous Region. Methods Pregnant women were classified into those with preeclampsia (n = 136) and healthy controls (n = 350). Serum levels of sFlt-1 and PlGF were quantified using a Roche serum instrument in both patients and controls. Results Compared to healthy controls, women with preeclampsia had significantly higher levels of sFlt-1 (7303.81 pg/ml vs. 2508.69 pg/ml, p < .001) and ratios of sFlt-1/PlGF (241.68 vs. 14.29, p < .001), whereas levels of PIGF were decreased (241.68 vs. 14.29, p < .001). These three values varied greatly across nationalities, and non-Han Chinese subjects (including Uygur, Kazak, Hui) were more likely to experience severe preeclampsia than Han Chinese subjects. Conclusions This is the first study to demonstrate that the ratio of sFlt-1/PlGF can both predict and serve as a diagnostic factor for preeclampsia in pregnant women from different populations within the Xinjiang region of China.
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