Abstract
Study Objective This study was the first to investigate the application of phthalocyanine green and nano-carbon suspension injection as a lymphatic tracer in laparoscopic radical resection of cervical cancer. The comparative value of its application in lymphatic imaging and sentinel lymph node identification was analyzed. The factors of the tracer results provide a reference for the application of clinical tracers. Design The patients were divided into nano-carbon group and indocyanine green group. Setting Xinxiang City Central Hospital Gynecologic Oncology, China. Patients or Participants Seventy-five patients with early stage cervical cancer were enrolled. Interventions Nano-carbon suspension injection and indocyanine green were injected from the cervix before operation, and black was recognized under laparoscopy. Lymph nodes and fluorescent lymph nodes were taken as SLN and excised. All patients underwent laparoscopic pelvic lymphadenectomy plus extensive hysterectomy (+ abdominal para-aortic lymph node sampling). All specimens were sent to routine examination. Measurements and Main Results There were no significant differences in age, tumor stage, and histological type between the two groups (P>0.05). SLN was detected in 25 cases of phthalocyanine green group, totaling 1006, the detection rate was 100%; the accuracy of SLN biopsy was 100%. There were 50 cases of nano-carbon suspension group, 39 cases of SLN were detected, a total of 1476, the discovery rate was 78%, the specificity was 76%; there was no statistical difference between the two groups (P> 0.05) However, the difference in the operation time between the two groups was statistically significant (P Conclusion The application of phthalocyanine green and nano-carbon suspension in the detection of SLN in cervical cancer is feasible, but the phthalocyanine green fluorescence detection method is more prominent in visual effect, which can significantly shorten the operation time.
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