Abstract
Summary 1. The foregoing study was carried out to obtain information about quinidine dosage in children, utilizing serum levels of the drug. 2. A method for determining serumquinidine concentration which is simple, can be run on capillary blood samples, and is sufficiently accurate for clinical use has been presented. 3. On the basis of body weight, infantsand young children appear to require relatively larger doses of quinidine than adults. 4. From information obtained instudies using single and multiple doses of quinidine, a tentative dosage schedule requiring a minimum of blood levels has been worked out. 5. A case has been presented inwhich the suggested dosage plan was successfully utilized to treat a 4-year-old child with congenital heart disease who had developed cardiac arrhythmia (impure auricular flutter). 6. Results which tended to vary from the normal were noted in patients with fever, with congestive heart failure, and with hydrocephalus; further work in these areas would be of particular interest.
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