A Study of Hepcidin Levels and Other Biochemical Parameters in Women with Osteoarthritis: As a Pharmaceutical Control

Abstract

Background: Hepcidin, one of the peptide hormones generated from the liver, can be defined as an important regulator regarding systemic iron homeostasis, while its lopsided production plays a role in the pathogenesis of a variety of iron diseases. Osteoarthritis (OA) frequently coexists with a number of diseases, including hemochromatosis, ß-thalassemia, cell disease, sickle cell disease, and hemosiderosis caused by iron overload. Evidence suggests that iron deficiency and iron overload negatively impact the bone, which acts immediately on the bone’s cells. The present work aims to determine whether a direct correlation exists between female patient’s OA and levels of hepcidin, DHVD3, and other indicators. Methods: A total of 60 participants were split into two groups for this work: 30 healthy controls and 30 female OA patients. This work was carried out from Nov. 2021 to the end of June. 2021. The ages ranged from (40 to 55). In Al-Mahmudiya Hospital and in Al-Yarmok Teaching Hospital, an endocrinologist assessed each one of the patients. We measured Hb, BMI, ferritin, hepcidin, DHVD3, iron, Ca, and PO4. Results: Hepcidin levels significantly increased, whereas ferritin, BMI, iron, vitamin D, calcium, and PO4 levels significantly decreased compared with the control group. However, alterations in lipid profile and glycemic profile were not statistically significant. Conclusion: By connecting low levels of iron, ferritin, calcium, vitamin D3, and PO4 with high levels of hepcidin in women with OA, it may be concluded that vitamin D3 insufficiency is associated with hepcidin malfunction as a factor affecting women with OA.