Abstract
AbstractThis paper presents the synthesis of epibatidine analogues by a straightforward one‐pot method for the synthesis of 7‐azabicyclo[2.2.1]heptane‐1‐carbonitriles, starting from cyclohexanones bearing a leaving group at the 4‐position. In situ imine formation, followed by reversible cyanide addition, allows complete conversion of 4‐(mesyloxy)cyclohexanone to the bicyclic core. Elaboration of the introduced nitrile functionality and deprotection of the tertiary amine leads to five new epibatidine analogues.
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