Abstract
A physiologically based human pharmacokinetic model of chemical intake via ingestion of food and water and inhalation of air is presented. The model takes the form of a series of algebraic equations that describe the steady state, constant exposure, transport rates and physiological distribution in arterial and venous blood, lung, fat, skin, muscle, liver, gut tissue, gut lumen and richly perfused tissues. It is assembled using the fugacity concept and is applied to a hexachlorobiphenyl and styrene. It is suggested that the model can be used to elucidate how tissue concentrations respond to these intake routes and thus should contribute to better assessment of the hazards or effects of exposure to organic chemicals on humans and other mammals.
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