Abstract
Background: Ubiquinone or Coenzyme Q (CoQ) is a molecule performing an essential function as an electron carrier in the respiratory chain. Besides, it functions as a proton and electron acceptor and as an antioxidant. It is composed of a benzoquinone ring and an isoprenoid chain, the last one being synthesized by a polyprenil diphosphate synthase. The inhibition of the Trypanosoma cruzi enzyme by 1-[(n-oct-1-ylamino) ethyl] 1,1-bisphosphonic acid (OBA) is lethal, as well as the interference of the homologous enzyme in T. brucei brucei. We now studied the OBA sensitivities of the different forms of human pathogenic trypanosomatids.
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