A special issue of IUBMB Life celebrating the 50th anniversary of FAOBMB (1972–2022)

Proceedings of the Australian Society for Medical Research.

Oligopeptide-binding protein A (OppA) from Lactococcus lactis binds peptides of an exceptionally wide range of lengths (4-35 residues), with no apparent sequence preference. Here, we present the crystal structures of OppA in the open- and closed-liganded conformations. The structures directly explain the protein's phenomenal promiscuity. A huge cavity allows binding of very long peptides, and a lack of constraints for the position of the N and C termini of the ligand is compatible with binding of peptides with varying lengths. Unexpectedly, the peptide's amino-acid composition (but not the exact sequence) appears to have a function in selection, with a preference for proline-rich peptides containing at least one isoleucine. These properties can be related to the physiology of the organism: L. lactis is auxotrophic for branched chain amino acids and favours proline-rich caseins as a source of amino acids. We propose a new mechanism for peptide selection based on amino-acid composition rather than sequence.

Binding of acetylcholine and cholinergic drugs to proteolipid fractions from rat cerebral cortex and to phospholipids from bovine brain

Annals of the New York Academy of SciencesVolume 971, Issue 1 p. 156-158 Influence of Ca2+ Removal Mechanisms on Catecholamine Secretion from Bovine Chromaffin Cells PHILIP D. MARLEY, Corresponding Author PHILIP D. MARLEY Department of Pharmacology, University of Melbourne, Victoria 3010, AustraliaAddress for correspondence: Philip D. Marley, Department of Pharmacology, University of Melbourne, Victoria 3010, Australia. Voice: +61-3-8344-6893; fax: +61-3-8344-0241; p.marley@unimelb.edu.au.Search for more papers by this authorSHARON H. A. WONG, SHARON H. A. WONG Department of Pharmacology, University of Melbourne, Victoria 3010, AustraliaSearch for more papers by this authorSACHA McKENZIE, SACHA McKENZIE Department of Pharmacology, University of Melbourne, Victoria 3010, AustraliaSearch for more papers by this author PHILIP D. MARLEY, Corresponding Author PHILIP D. MARLEY Department of Pharmacology, University of Melbourne, Victoria 3010, AustraliaAddress for correspondence: Philip D. Marley, Department of Pharmacology, University of Melbourne, Victoria 3010, Australia. Voice: +61-3-8344-6893; fax: +61-3-8344-0241; p.marley@unimelb.edu.au.Search for more papers by this authorSHARON H. A. WONG, SHARON H. A. WONG Department of Pharmacology, University of Melbourne, Victoria 3010, AustraliaSearch for more papers by this authorSACHA McKENZIE, SACHA McKENZIE Department of Pharmacology, University of Melbourne, Victoria 3010, AustraliaSearch for more papers by this author First published: 24 January 2006 https://doi.org/10.1111/j.1749-6632.2002.tb04454.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume971, Issue1THE CHROMAFFIN CELL: TRANSMITTER BIOSYNTHESIS, STORAGE, RELEASE, ACTIONS, AND INFORMATICS: 11th INTERNATIONAL SYMPOSIUM ON CHROMAFFIN CELL BIOLOGYOctober 2002Pages 156-158 RelatedInformation

1 Pathology, The University of Melbourne, Melbourne, VIC, Australia 2 The Mental Health Research Institute, Melbourne, VIC, Australia 3 Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia 4 School of Chemistry, The University of Melbourne, Melbourne, VIC, Australia 5 Neuroproteomics and Neurogenomics Platform, National Neuroscience Facility, Melbourne, VIC, Australia 6 Centre for Neuroscience, The University of Melbourne, Melbourne, VIC, Australia

AllergyVolume 26, Issue 4 p. 286-290 THE PRODUCTION AND EFFECTIVITY OF RABBIT ANTISERUM AGAINST VESPA ORIENTALIS VENOM J. ISHAY, J. ISHAY Department of Physiology and Pharmacology, Tel-Aviv University Medical School, and Department of Biochemistry, Beilinson Hospital, Petah-Tiqva, Israel.Search for more papers by this authorS. GITTER, S. GITTER Department of Physiology and Pharmacology, Tel-Aviv University Medical School, and Department of Biochemistry, Beilinson Hospital, Petah-Tiqva, Israel.Search for more papers by this authorJ. FISCHL, J. FISCHL Department of Physiology and Pharmacology, Tel-Aviv University Medical School, and Department of Biochemistry, Beilinson Hospital, Petah-Tiqva, Israel.Search for more papers by this author J. ISHAY, J. ISHAY Department of Physiology and Pharmacology, Tel-Aviv University Medical School, and Department of Biochemistry, Beilinson Hospital, Petah-Tiqva, Israel.Search for more papers by this authorS. GITTER, S. GITTER Department of Physiology and Pharmacology, Tel-Aviv University Medical School, and Department of Biochemistry, Beilinson Hospital, Petah-Tiqva, Israel.Search for more papers by this authorJ. FISCHL, J. FISCHL Department of Physiology and Pharmacology, Tel-Aviv University Medical School, and Department of Biochemistry, Beilinson Hospital, Petah-Tiqva, Israel.Search for more papers by this author First published: August 1971 https://doi.org/10.1111/j.1398-9995.1971.tb01301.xCitations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume26, Issue4August 1971Pages 286-290 RelatedInformation

Journal Article Corrected proof Caveats for Validating the Diagnostic Accuracy of Diagnostic or Classification Criteria for Infective Endocarditis Get access Shungo Yamamoto Shungo Yamamoto Department of Transformative Infection Control Development Studies, Osaka University Graduate School of Medicine, Osaka, JapanDivision of Fostering Required Medical Human Resources, Center for Infectious Disease Education and Research, Osaka University, Osaka, JapanDivision of Infection Control and Prevention, Osaka University Hospital, Suita, Osaka, Japan Correspondence: S. Yamamoto, Department of Transformative Infection Control Development Studies, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, Japan, 565-0871 (shungo1977@cider.osaka-u.ac.jp). https://orcid.org/0000-0003-3207-8403 Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, ciad395, https://doi.org/10.1093/cid/ciad395 Published: 29 June 2023 Article history Published: 29 June 2023 Corrected and typeset: 18 July 2023

British Journal of Pharmacology and ChemotherapyVolume 5, Issue 3 p. 395-397 Free Access SPECIFIC AND NON-SPECIFIC SERUM CHOLINESTERASE IN CATS BEFORE AND AFTER TREATMENT WITH STILBOESTROL R. E. DAVIES, R. E. DAVIES Medical Research Council Unit for Research in Cell Metabolism, Department of Biochemistry and the Department of Pharmacology and Therapeutics, University of SheffieldSearch for more papers by this authorK. N. OJHA, K. N. OJHA Medical Research Council Unit for Research in Cell Metabolism, Department of Biochemistry and the Department of Pharmacology and Therapeutics, University of Sheffield Government of India scholar.Search for more papers by this author R. E. DAVIES, R. E. DAVIES Medical Research Council Unit for Research in Cell Metabolism, Department of Biochemistry and the Department of Pharmacology and Therapeutics, University of SheffieldSearch for more papers by this authorK. N. OJHA, K. N. OJHA Medical Research Council Unit for Research in Cell Metabolism, Department of Biochemistry and the Department of Pharmacology and Therapeutics, University of Sheffield Government of India scholar.Search for more papers by this author First published: September 1950 https://doi.org/10.1111/j.1476-5381.1950.tb00588.xCitations: 2 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume5, Issue3September 1950Pages 395-397 ReferencesRelatedInformation

Annals of the New York Academy of SciencesVolume 171, Issue 3 p. 882-894 ROLE OF POLYAMINES IN REPRODUCTIVE PHYSIOLOGY AND SEX HORMONE ACTION* H. G. Williams-Ashman Ph.D., H. G. Williams-Ashman Ph.D. The Ben May Laboratory for Cancer Research and Department of Biochemistry, University of Chicago, Chicago, Ill., and Departments of Pharmacology and Experimental Therapeutics and of Medicine, John Hopkins University School of Medicine, Baltimore, Md.Search for more papers by this authorD. H. Lockwood M.D., D. H. Lockwood M.D. The Ben May Laboratory for Cancer Research and Department of Biochemistry, University of Chicago, Chicago, Ill., and Departments of Pharmacology and Experimental Therapeutics and of Medicine, John Hopkins University School of Medicine, Baltimore, Md.Search for more papers by this author H. G. Williams-Ashman Ph.D., H. G. Williams-Ashman Ph.D. The Ben May Laboratory for Cancer Research and Department of Biochemistry, University of Chicago, Chicago, Ill., and Departments of Pharmacology and Experimental Therapeutics and of Medicine, John Hopkins University School of Medicine, Baltimore, Md.Search for more papers by this authorD. H. Lockwood M.D., D. H. Lockwood M.D. The Ben May Laboratory for Cancer Research and Department of Biochemistry, University of Chicago, Chicago, Ill., and Departments of Pharmacology and Experimental Therapeutics and of Medicine, John Hopkins University School of Medicine, Baltimore, Md.Search for more papers by this author First published: October 1970 https://doi.org/10.1111/j.1749-6632.1970.tb39395.xCitations: 59 * Work from the authors' laboratories was supported in part by a research grant (HD-04593) from the U. S. Public Health Service and a grant-in-aid from the Gustavus and Louise Pfeiffer Research Foundation. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume171, Issue3Metabolism and Biological Functions of PolyminesOctober 1970Pages 882-894 RelatedInformation

Journal Article Effect of histamine on the resting and stimulation-induced release of [3H]noradrenaline from rat isolated atria Get access M J Rand, M J Rand Department of Pharmacology, University of Melbourne, Victoria, 3052, Australia Search for other works by this author on: Oxford Academic Google Scholar D F Story, D F Story Department of Pharmacology, University of Melbourne, Victoria, 3052, Australia Search for other works by this author on: Oxford Academic Google Scholar H K Wong-Dusting H K Wong-Dusting Department of Pharmacology, University of Melbourne, Victoria, 3052, Australia Correspondence. Department of Pharmacology, University of Melbourne, Victoria, 3052, Australia Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 35, Issue 2, February 1983, Pages 126–128, https://doi.org/10.1111/j.2042-7158.1983.tb04287.x Published: 12 April 2011 Article history Received: 12 July 1982 Published: 12 April 2011

Extracellular vesicles (EVs) are membranous nanoparticles produced by most cell types into the extracellular space and play an important role in cell-to-cell communication. Historically, EVs were categorized based on their methods of biogenesis and size into three groups: exosomes, microvesicles, and apoptotic bodies. Most recently, EV nomenclature has evolved to categorize these nanoparticles based on their size, surface markers, and/or the cell type which secreted them. Many techniques have been adopted in recent years which leverage these characteristics to isolate them from cell culture media and biological fluids. EVs carry various “cargo”, including DNA, RNA, proteins, and small signaling molecules. After isolation, EVs can be characterized by various methods to analyze their unique cargo profiles which define their role in cell-to-cell communication, normal physiology, and disease progression. The study of EV cargo has become more common recently as we continue to delineate their role in various human diseases. Further understanding these mechanisms may allow for the future use of EVs as novel biomarkers and therapeutic targets in diseases. Furthermore, their unique cargo delivery mechanisms may one day be exploited to selectively deliver therapeutic agents and drugs. Despite the growing research interest in EVs, limited studies have focused on the role of EVs in the diseases of the ear, nose, and throat. In this review, we will introduce EVs and their cargo, discuss methods of isolation and characterization, and summarize the most up-to-date literature thus far into the role of EVs in diseases of the ear, nose, and throat.

Medical Journal of AustraliaVolume 2, Issue 26 p. 1331-1335 Clinical Review ADRENORECEPTOR CLASSIFICATION C. RAPER B.PHARM.(HON.), PH.D. (LOND.), PH.C., M.P.S., C. RAPER B.PHARM.(HON.), PH.D. (LOND.), PH.C., M.P.S. Department of Pharmacology, University of MelbourneSearch for more papers by this authorMarian W. McCulloch B.SC. (LOND.), M.SC., PH.D. (MELB.), Marian W. McCulloch B.SC. (LOND.), M.SC., PH.D. (MELB.) Department of Pharmacology, University of Melbourne1 Address for reprints: Dr M. W. McCulloch, Department of Pharmacology, University of Melbourne, Parkville, Vic. 3052.Search for more papers by this author C. RAPER B.PHARM.(HON.), PH.D. (LOND.), PH.C., M.P.S., C. RAPER B.PHARM.(HON.), PH.D. (LOND.), PH.C., M.P.S. Department of Pharmacology, University of MelbourneSearch for more papers by this authorMarian W. McCulloch B.SC. (LOND.), M.SC., PH.D. (MELB.), Marian W. McCulloch B.SC. (LOND.), M.SC., PH.D. (MELB.) Department of Pharmacology, University of Melbourne1 Address for reprints: Dr M. W. McCulloch, Department of Pharmacology, University of Melbourne, Parkville, Vic. 3052.Search for more papers by this author First published: 01 December 1971 https://doi.org/10.5694/j.1326-5377.1971.tb92875.xCitations: 8 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume2, Issue26December 1971Pages 1331-1335 RelatedInformation

William "Bill" Joseph Whelan, D.Sc., FRS November 14, 1924 to June 5, 2021.

1Department of Biochemistry &Molecular Biology, Bio21Molecular Sciences and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia 2Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China 3Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, Canada H3T 1E2 4The Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3T 1E2 5Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3052, Australia

Erratum to “Domain Organization of the Monomeric Form of the Tom70 Mitochondrial Import Receptor” [J. Mol. Biol. 388 (2009) 1043–1058