Abstract
The light (L) strand sequence of HeLa cell mitochondrial DNA which codes for a small polyadenylated RNA (7 S RNA) has been precisely localized, by mapping and sequencing studies, in a region of the genome which immediately precedes the origin of replication in the direction of L-strand transcription, extending from 219 nucleotides to within 20 nucleotides from this origin. A 5′-end sequencing analysis of 7 S RNA has revealed the presence of two major species differing in size by one nucleotide at this end, and possibly three minor species. The 7 S RNA appears to contain, near its 3′-end, a potential reading frame for a polypeptide 23 or 24 amino acids long. Furthermore, in the 5′ non-coding region, an 11-nucleotide long sequence has been identified which is complementary to a sequence near the 3′-end of the 12 S ribosomal RNA, and possibly represents a ribosome attachment site.
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