Molecular Biology of the Cell | VOL. 33
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A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

Publication Date Nov 1, 2022

Abstract

RNF5 has multiple biological roles and has been linked to the development of severe diseases such as cystic fibrosis, acute myeloid leukemia, and certain viral infections. This study developed a small molecule inhibitor and degrader of the RNF5 ubiquitin ligase, providing a chemical biology tool for RNF5 research and therapeutic development.

Concepts

Acute Myeloid Leukemia Small Molecule Degrader Cystic Fibrosis Inhibitor Of Ligase Therapeutic Development Viral Infections Chemical Tool Tool For Research Multiple Roles Tool For Development

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