Abstract
The effects of viral inhibitors, guanidine and 2-(α-hydroxybenzyl)-benzimidazole (HBB), on enterovirus RNA synthesis and multiplication were studied in single HeLa or monkey kidney cells. Guanidine interrupted ongoing synthesis of viral RNA and production of infectious virus in single cells infected with poliovirus. Similarly, HBB halted ongoing replication of ECHO type 12 virus in single cells. Conversely, the presence of guanidine was necessary for continued synthesis of viral RNA and replication of virus in single cells infected with guanidine-dependent poliovirus type 1. Puromycin and guanidine inhibited ongoing poliovirus RNA synthesis with equal rapidity. The demonstrated effects of these drugs in single cells during the incremental phase in the viral growth cycle add evidence in support of the hypothesis that enterovirus RNA polymerase is synthesized throughout the exponential increase of virus.
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