Abstract
A brief method is described for the assessment of lethal toxicity of ricin and ricinus agglutinin using a modified LD 50 assay. With this test, it is possible to obtain an LD 50 using only 10 experimental animals. The equation for calculating the confidence limit of LD 50 is derived in this article. The LD 50 values obtained with the method were compared with data reported in the literature using classical methods. The results indicate that the simplified method for evaluating the acute toxicity of ricin and ricinus agglutinin gives reliable results. For scientific, economic and ethical reason the method is suggested to replace the traditional LD 50 assay for plant toxins.
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