A simple self-assembly fabrication of tin oxide nanoplates on multiwall carbon nanotubes for selective and sensitive electrochemical determination of antipyretic drug

Abstract

An attempt has been made in this work to construct a hybrid nanocomposite sensor for highly selective and sensitive recognition of antipyretic drug acetaminophen (ACOP). The hybrid nanocomposite based electrocatalyst is developed by an efficient self-assembling approach. In this concern, tin oxide (SnO2) nanoplates are synthesized and grafted onto the beta-cyclodextrin (β-CD) covered multiwall carbon nanotubes (MWCNTs) (SnO2@MWCNT/β-CD) for the first time. The presence of β-CD plays a dynamic role in both formation of hybrid nanocomposite and selective sensing. The characterization and the formation mechanism of hybrid nanocomposite have discussed from the results of Fourier transform infrared (FT-IR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), and X-ray diffraction (XRD) analysis. Then the hybrid nanocomposite modified glassy carbon electrode was optimized with the effect of different electrode composition and different pH to find the optimum working condition to get a better response for ACOP. At the optimized conditions, the developed sensor shows the wide linear range (0.01 − 340 μM) and low detection limit (5.8 nM). The synergetic effect of the constituents makes a direct linkage for electron transfer from ACOP to the electrode surface and thus improves the response signal with long-term stability. Furthermore, the designed sensor shows good selectivity, reproducibility, and good recovery results in a tablet and human urine samples.