Abstract
In the present study, use of MgFe2O4@SiO2-SO3H as an efficient, green, magnetically recoverable & recyclable catalyst for micro-wave assisted solvent free synthesis of 2,3-dihydroquinazolin-4(1H)-ones reaction pathway is presented. The superiorities of this method are higher conversion rate, shorter reaction time, easy isolation of product and reusability of catalyst without remarkable loss of activity. The synthesized 2,3-dihydroquinazolin-4(1H)-ones derivatives were assessed for their antimicrobial and antifungal activity; where, the most of these compounds exhibit potent antibacterial and antifungal activities against various bacteria and fungi.
Highlights
The development of green catalyst and its reactions are the necessity for sustainable and green chemistry
Various catalysts have been reported for multicomponent synthesis of quinazolinones from isatoic anhydride, aldehydes and amines and ammonium acetate
The reusability of MgFe2O4@SiO2-SO3H was studied by choosing the model reaction of isatoic anhydride, ammonium acetate and benzaldehyde in the presence of MgFe2O4@SiO2SO3H under solvent-free condition
Summary
A Simple and Convenient Synthesis of 2, 3-dihydroquinazolin-4(1H)-one Derivatives using MgFe2O4@SiO2-SO3H Catalyst. Anand Shankar Aswar1,*, , Nilesh Govindrao Salunkhe, Chandrashekhar Arun Ladole, Nikita Vinod Thakare, Jagruti Manish Barabde. Use of MgFe2O4@SiO2-SO3H as an efficient, green, magnetically recoverable & recyclable catalyst for micro-wave assisted solvent free synthesis of 2,3dihydroquinazolin-4(1H)-ones reaction pathway is presented. The superiorities of this method are higher conversion rate, shorter reaction time, easy isolation of product and reusability of catalyst without remarkable loss of activity. The synthesized 2,3-dihydroquinazolin-4(1H)-ones derivatives were assessed for their antimicrobial and antifungal activity; where, the most of these compounds exhibit potent antibacterial and antifungal activities against various bacteria and fungi
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