A silk fibroin based bioadhesive with synergistic photothermal-reinforced antibacterial activity

Abstract

Bioadhesives have gained considerable popularity for application in wound closure. However, applying bioadhesives incurs risks associated with bacterial infection during wound healing. Hence, in this study, a silk fibroin based bioadhesive was constructed via employing natural macromolecule, silk fibroin (SF), to spontaneously coassemble with natural plant polyphenol, tannic acid (TA), and iron oxide nanoparticles (Fe3O4 NPs). In the system, the natural macromolecule SF plays a key role in fabricating the macromolecular network matrix due to the change of the secondary structure of SF (from random coil to β-sheet) under the trigger of TA. Importantly, the strong hydrogen bonding interactions between SF and TA, and the coordination bonds between TA and Fe3O4 NPs endow the bioadhesive with high extensibility, self-healing properties, and considerable wet adhesion. Meanwhile, the synergy between the inherent photothermal properties of Fe3O4 NPs and TA/Fe3+ complexes under near-infrared (NIR) radiation enables the bioadhesive superior photothermal-reinforced antibacterial activity. The multifunctional natural macromolecule bioadhesive is a potential candidate in clinical wound management for improved outcomes, especially in infected wounds.