Abstract
Tendon disease constitutes an unmet clinical need and remains a critical challenge in the field of orthopaedic surgery. Innovative solutions are required to overcome the limitations of current tendon grafting approaches, and bioelectronic therapies show promise in treating musculoskeletal diseases, accelerating functional recovery through the activation of tissue regeneration-specific signaling pathways. Self-powered bioelectronic devices, particularly piezoelectric materials, represent a paradigm shift in biomedicine, negating the need for battery or external powering and complementing existing mechanotherapy to accelerate the repair processes. Here, the dynamic response of tendon cells to a piezoelectric collagen-analogue scaffold comprised of aligned nanoscale fibers made of the ferroelectric material poly(vinylidene fluoride-co-trifluoroethylene) is shown. It is demonstrated that motion-powered electromechanical stimulation of tendon tissue through piezo-bioelectric device results in ion channel modulation in vitro and regulates specific tissue regeneration signaling pathways. Finally, the potential of the piezo-bioelectronic device in modulating the progression of tendinopathy-associated processes in vivo, using a rat Achilles acute injury model is shown. This study indicates that electromechanical stimulation regulates mechanosensitive ion channel sensitivity and promotes tendon-specific over non-tenogenic tissue repair processes.
Highlights
Tendon disease constitutes an unmet clinical need and remains a critical place a considerable burden on healthcare systems
This work shows that tendon cell biological function and tissue repair processes can be modulated by mechanical and electromechanical stresses
We improved the therapeutic performance of the implantable devices by enhancing the physicomechanical, piezoelectric, and biological characteristics through a short-distance electrospinning process followed by fibronectin functionalization
Summary
Tendon disease constitutes an unmet clinical need and remains a critical place a considerable burden on healthcare systems Innovative solutions are required post-surgery complications result in nearly to overcome the limitations of current tendon grafting approaches, and bioelectronic therapies show promise in treating musculoskeletal diseases, accelerating functional recovery through the activation of tissue regenerationspecific signaling pathways. Following injury, disorganized tissue deposition leads to scar tissue formation, proteoglycan accumulation, and calcification, resulting in poor biomechanical properties and impaired function that powered electromechanical stimulation of tendon tissue through piezotriggers chronic inflammatory signaling bioelectric device results in ion channel modulation in vitro and regulates specific tissue regeneration signaling pathways. This study indicates that electromechanical stimulation regulates paradigm shift in the field of biomedical mechanosensitive ion channel sensitivity and promotes tendon-specific over devices and regenerative medicine (RM).[4].
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