Abstract
The method developed here for calculating the selection coefficient for Rh-rh individuals due to immunization of rh-rh women against the blood-group factor “Rhesus positive” allows of considerable adjustment to differences in population structure and to the rank of the immunizing pregnancy. Even this method, however, does not embrace certain peculiarities of Rhesus immunization, e.g. differences of immunization in Rhesus subgroups and protection by ABO incompatibility. The following conclusions can be drawn with regard to the dynamics of the Rhesus gene in Europidy populations: if the observed high frequency of rh genes was balanced by selection favouring surviving heterozygotes under conditions with a high average number of births then receding selection due to restricted reproduction must result in an increase of the frequency of rh genes until a new state of equilibrium has been attained. If no selection favouring heterozygotes is present it must be assumed that the frequency of the rh genes was on the decrease in earlier generations. A diminished degree of selection is expected to slow this decline.
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