A screening study on the mutagen formation potential of 44 pesticides

Abstract

Research Article| February 01 2013 A screening study on the mutagen formation potential of 44 pesticides Hirokazu Takanashi; Hirokazu Takanashi 1Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima, Kagoshima, 890-0065, Japan E-mail: takanashi@apc.kagoshima-u.ac.jp Search for other works by this author on: This Site PubMed Google Scholar Misako Kishida; Misako Kishida 1Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima, Kagoshima, 890-0065, Japan Search for other works by this author on: This Site PubMed Google Scholar Kazuya Abiru; Kazuya Abiru 1Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima, Kagoshima, 890-0065, Japan Search for other works by this author on: This Site PubMed Google Scholar Takashi Kondo; Takashi Kondo 2Division of Natural Environment and Information, Faculty of Environment and Information Sciences, Yokohama National University, 79-7, Tokiwadai, Hodogaya, Yokohama, 240-8501, Japan Search for other works by this author on: This Site PubMed Google Scholar Takashi Kameya; Takashi Kameya 2Division of Natural Environment and Information, Faculty of Environment and Information Sciences, Yokohama National University, 79-7, Tokiwadai, Hodogaya, Yokohama, 240-8501, Japan Search for other works by this author on: This Site PubMed Google Scholar Taku Matsushita; Taku Matsushita 3Department of Environmental Engineering, Graduate School of Engineering, Hokkaido University, N13W8, Sapporo, 060-8628, Japan Search for other works by this author on: This Site PubMed Google Scholar Tsunenori Nakajima; Tsunenori Nakajima 1Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima, Kagoshima, 890-0065, Japan Search for other works by this author on: This Site PubMed Google Scholar Akira Ohki Akira Ohki 1Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima, Kagoshima, 890-0065, Japan Search for other works by this author on: This Site PubMed Google Scholar Journal of Water Supply: Research and Technology-Aqua (2013) 62 (1): 14–22. https://doi.org/10.2166/aqua.2013.021 Article history Received: February 05 2012 Accepted: December 11 2012 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Cite Icon Cite Permissions Search Site Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsThis Journal Search Advanced Search Citation Hirokazu Takanashi, Misako Kishida, Kazuya Abiru, Takashi Kondo, Takashi Kameya, Taku Matsushita, Tsunenori Nakajima, Akira Ohki; A screening study on the mutagen formation potential of 44 pesticides. Journal of Water Supply: Research and Technology-Aqua 1 February 2013; 62 (1): 14–22. doi: https://doi.org/10.2166/aqua.2013.021 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex The mutagenicity and the mutagen formation potential (MFP) of seven fungicides, 15 herbicides and 22 insecticides upon chlorination were measured with the Ames Salmonella assay. All the pesticides except for thiram and dichlorvos were non-mutagenic. However, 75% of the tested pesticides showed significant MFP. This indicated that the chlorination by-products of some pesticides are mutagenic, although the pesticides themselves are not. No significant mutagenicity or MFP was observed for 20% of the pesticides tested in the present study. Thiram and dichlorvos, representing 5% of the tested pesticides, had significant mutagenicity and MFP. The average MFP of asulam, which had the highest MFP in this study, was 860 times greater than the average MFP of propyzamide, which had the lowest MFP (below the detection limit). In addition, the chemical structures of pesticides which had significant MFPs were compared to each other in order to see if there are common characteristics among them, but we could not predict whether pesticides are capable of forming mutagens from their chemical structures, use types or mode of actions. MFP measurements are indispensable in order to know whether pesticides are capable of forming mutagens. Ames assay, chlorination by-product, mutagen formation potential (MFP), mutagenicity This content is only available as a PDF. © IWA Publishing 2013 You do not currently have access to this content.