Abstract
Glucose, as an essential substance directly involved in metabolic processes, is closely related to the occurrence of various diseases such as glucose metabolism disorders and islet cell carcinoma. Therefore, it is crucial to develop sensitive, accurate, rapid, and cost effective methods for frequent and convenient detections of glucose. Microfluidic Paper-based Analytical Devices (μPADs) not only satisfying the above requirements but also occupying the advantages of portability and minimal sample consumption, have exhibited great potential in the field of glucose detection. This article reviews and summarizes the most recent improvements in glucose detection in two aspects of colorimetric and electrochemical μPADs. The progressive techniques for fabricating channels on μPADs are also emphasized in this article. With the growth of diabetes and other glucose indication diseases in the underdeveloped and developing countries, low-cost and reliably commercial μPADs for glucose detection will be in unprecedentedly demand.
Highlights
IntroductionOne of the essential metabolic intermediates, is an important medical analyte which is the indicator of various diseases, such as glucose metabolism disorders and islet cell carcinoma [1,2,3,4]
Glucose, one of the essential metabolic intermediates, is an important medical analyte which is the indicator of various diseases, such as glucose metabolism disorders and islet cell carcinoma [1,2,3,4].Normally, the concentration of glucose in human blood stream is in the range of 3.8–6.9 mM
Anodic currents given by electrodes were proportional to the glucose concentrations and linearity is up to 10 mM, which is sufficient for clinical applications [6]
Summary
One of the essential metabolic intermediates, is an important medical analyte which is the indicator of various diseases, such as glucose metabolism disorders and islet cell carcinoma [1,2,3,4]. Microfluidic paper-based analytical devices (μPADs) as a promising and powerful platform have shown great potential in the development of POCTs [20,21,22,23,24]. This concept was first proposed by the Whitesides group in 2007 [14] and the photoresist-patterned paper was used to fabricate. With the development of microfabrication and nanomaterial, glucose detection μPADs with high sensitivity and stability will be commercially accessible in the near future
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
