Abstract
Gastroretentive drug delivery system comprised mainly of floating, bioadhesive, swelling, high density and magnetic systems have emerged as a current approaches of enhancing the bioavailability and controlled delivery of drugs that exhibit an absorption window. By prolonging the gastric emptying time of the dosage form, these systems not only provide controlled release of the drug for a prolonged period but also present the drug in an absorbable form at regions of optimal absorption. CR-GRDF provides a means to utilize all the pharmacokinetic (PK) and pharmacodynamic (PD) advantages of controlled release dosage forms for such drugs. Due to the complexity of pharmacokinetic and pharmacodynamic parameters, in vivo studies are required to establish the optimal dosage form for a specific drug. For a certain drug, interplay of its pharmacokinetic and pharmacodynamic parameters will determine the effectiveness and benefits of the CRGRDF compared to the other dosage forms.
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