International Journal for Research in Applied Science and Engineering Technology | VOL. 10

A Review on Downstream Processing of Monoclonal Antibodies (mAbs)

Publication Date Nov 30, 2022


Abstract: The creation of therapeutic monoclonal antibodies has increased recently. mAbs have grown significantly in relevance, and these compounds are now more crucial than ever in the global biotechnological drug industry. For the treatment of various diseases, a lot of biotechnology companies are investing in the manufacture of monoclonal antibodies. The two main processes in the synthesis of these antibodies are bioreactor production and purification. This article goes into great detail on the current purification techniques utilized for these compounds. The fundamental monoclonal antibody recovery and purification procedures, including cell harvesting, Protein A affinity chromatography, and further polishing steps, are all enumerated.


Manufacture Of Monoclonal Antibodies Bioreactor Production Monoclonal Antibodies Purification Procedures Manufacture Of Antibodies Monoclonal Antibody Purification Main Processes Affinity Chromatography Global Drug Antibody Purification

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