Abstract
To review large cohort genome wide association studies for erectile dysfunction. Two recent genome wide association studies using the Genetic Epidemiology Research in Adult Health and Aging cohort, UK Biobank, and the Partners HealthCare Biobank have identified an association between unique single nucleotide polymorphisms involved in the regulatory activity of single-minded homolog 1 (SIM1) and risk of erectile dysfunction. SIM1 is involved in the leptin-melanocortin pathway and may contribute to centrally mediated erectile dysfunction. Identification of novel loci associated with erectile function from genome wide association studies will help expand the understanding of the breadth of pathways that contribute to erectile dysfunction. This will help accelerate studies of novel therapies for the treatment of erectile dysfunction.
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