Abstract
Synergistic effects of fibrinolytic and additional antithrombotic treatment during cardiopulmonary resuscitation in out-of-hospital cardiac arrest of assumed cardiac origin were evaluated retrospectively. Data were drawn from electronic files of the physician-staffed Emergency Medical Services Tyrol. During a 22-month observation period 53 adult patients were treated with tenecteplase (mean 7641 IU), 19 (32.1%) of whom received additional antithrombotic treatment with heparin (4000–5000 IU) and acetylsalicylic acid (250–500 mg). Lasting return of spontaneous circulation occurred in four of 34 patients who received fibrinolytic treatment only and in seven of 19 patients with additional antithrombotic treatment (p = 0.037). Four of five patients who were discharged from hospital had received additional antithrombotic treatment during CPR and were in appropriate neurological status (CPC 1). Considering the small sample size in this retrospective study, the argument may be still be made that fibrinolytic and adjunctive antithrombotic treatment during cardiopulmonary resuscitation in out-of-hospital cardiac arrest of assumed cardiac origin may increase the chances for survival.
Highlights
Synergistic effects of fibrinolytic and additional antithrombotic treatment during cardiopulmonary resuscitation in out-of-hospital cardiac arrest of assumed cardiac origin were evaluated retrospectively
Even in the absence of fibrinolytic treatment, prehospital administration of acetylsalicylic acid (ASA) and heparin was associated with improved survival to hospital discharge and with favorable neurological outcome at hospital d ischarge[10]
In this retrospective study we evaluated whether additional administration of heparin and ASA to tenecteplase during cardiopulmonary resuscitation (CPR) was associated with a higher frequency of return of spontaneous circulation (ROSC) and improved outcome
Summary
Synergistic effects of fibrinolytic and additional antithrombotic treatment during cardiopulmonary resuscitation in out-of-hospital cardiac arrest of assumed cardiac origin were evaluated retrospectively. Fibrinolytic treatment during cardiopulmonary resuscitation (CPR) is recommended in the current European Resuscitation Council (ERC) Guidelines for Resuscitation in patients suffering out-of-hospital cardiac arrest (OHCA) from suspected or confirmed pulmonary artery embolism (PAE)[1] Despite their proven effectiveness many emergency physicians are reluctant to administer fibrinolytics in the out-of-hospital setting[2]. Even in the absence of fibrinolytic treatment, prehospital administration of acetylsalicylic acid (ASA) and heparin was associated with improved survival to hospital discharge and with favorable neurological outcome at hospital d ischarge[10] In this retrospective study we evaluated whether additional administration of heparin and ASA to tenecteplase during CPR was associated with a higher frequency of return of spontaneous circulation (ROSC) and improved outcome
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
