Abstract
SARS-CoV2 continues to affect the lives of the majority of the world, and although vaccines are beginning to become available, much of the world will still be unable to obtain them. Furthermore, some studies have suggested that there may have to be annual vaccines and as strains of the virus continue to increase, it is essential for us to move to the next stage of research and attempt to better understand the virus.
 By utilizing a chemical genetics approach where numerous ligands of distinct chemical libraries are screened through high-throughput screening, we may be able to form an ordered viral cycle of metabolic events that could help identify drug targets more efficiently and coordinate drug use to improve efficacy. A modified version of the virus (to decrease its ability of infection) along with the URA3 protein is then inserted into yeast cells (Saccharomyces cerevisiae) and screened. A simple assay involving the addition of 5’- fluoroorotic acid helps to determine ligand interference and after identifying the compounds, we can order their action into specific steps in the lifecycle and order the events of the life cycle.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
