A reprodukciós öregedés és a csontszerkezet változásának kapcsolata nőknél

Abstract

The main purpose of the study was to analyse the relationship between menopausal status and the bone structure in women. A random sample of 1932 Hungarian women (aged 25–95 years) was to be enrolled in the study between 2012 and 2015. Bone mass was estimated by the Drinkwater–Ross anthropometric four-component method. Bone structure parameters were assessed by a quantitative ultrasound DTU-one device. Subjects were divided into menopausal subgroups on the basis of their menstrual history. The risk of osteoporosis was identified by using the thresholds of ultrasound parameters recommended for the DTU-one device. The ultrasound parameters’ reference values were constructed in the studied age-group of Hungarian women for the DTU-one sonometer. An intensive, menopause-related change from the late 40s and a significant change from the beginning of the 70s were observed in the bone structure of women. The 15–17% of women were at very high risk for osteoporosis in the premenopausal status subgroup. After the menopausal transition the decreased level of female sex hormone production doubled this risk of osteoporosis for the beginning of the postreproductive period, and triplicated this risk in the 70s of women. Premature menopause was found to be accompanied by the increased risk of osteoporosis during the whole studied age interval.