Abstract
Chromosomes,the longest molecular fiber that stores genetic information in eukaryotic cells,must be orderly packaged during mitosis for their proper segregation into daughter cells.Although the morphological changes of chromosomes during mitosis have been described in detail,how mitosis progression programs the transformation of seemingly amorphous and loose interphase chromosomes into highly characteristic mitotic chromosomes remains a classical problem in cell biology.Strikingly,the chromo-
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