Abstract
Background It has been noticed by our group [1] that p-chloroamphetamine (PCA)-induced SERT current ''deactivates'' slower upon removal of PCA from the external solution, when compared to the deactivation of serotonin (5-HT)induced current. This was observed in stably transfected human embryonic kidney (HEK) cells as well as in Xenopus laevis oocytes injected with hSERT-RNA, for PCA/5-HT concentrations between 1 and 30 μM. Following the removal of higher concentrations of PCA (>30 μM) from the bath solution we witnessed an intriguing, but yet paradoxical current rise.
Highlights
15th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Andrea Laslop and Thomas Griesbacher Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S2-info.pdf . It has been noticed by our group [1] that p-chloroamphetamine (PCA)-induced SERT current ''deactivates'' slower upon removal of PCA from the external solution, when compared to the deactivation of serotonin (5-HT)induced current
This was observed in stably transfected human embryonic kidney (HEK) cells as well as in Xenopus laevis oocytes injected with hSERT-RNA, for PCA/5-HT concentrations between 1 and 30 μM
We try to explain both findings with a model in which due to PCA leakage from the interior of the cell, SERT activity is prolonged
Summary
A relationship between membrane permeability of amphetamines and serotonin efflux via serotonin transporters. Address: Institute of Pharmacology, Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Published: 12 November 2009 BMC Pharmacology 2009, 9(Suppl 2):A37 doi:10.1186/1471-2210-9-S2-A37. 15th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Andrea Laslop and Thomas Griesbacher Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S2-info.pdf
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