Abstract
Genetic manipulation of signaling proteins is an important tool to study signaling mechanisms. While rabbit sinoatrial node cells (SANC) are an excellent model for the study of autonomic signaling, genetic manipulation of freshly isolated rabbit SANC (f-SANC) is not possible. Here we report important characteristics of a cultured rabbit SANC model (c-SANC) that is suitable for manipulation of gene expression. C-SANC generate regular and rhythmic APs at 34±0.5oC, and beat spontaneously at a lower rate (1.35±0.02Hz, n=803) than f-SANC (2.79±0.04Hz, n=203 p<0.001).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
