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Abstract
Leptospirosis is an emerging zoonotic disease with globally public health problem in both animals and humans. Currently, there is no effective vaccine to prevent most of the circulating serovars in Vietnam because ofthe diversity of among leptospiral serovars. In this study, a highly immunogenic epitopes from LipL21 were designed using an in-silico approach. The recombinant protein was constructed from conserved sequences of five Leptospira interrogans isolated Vietnamese strains. Immunization of mice with multi-epitope protein resulted in the antibodies production, as evidenced by MAT. Recombinant proteins can also significantly reduce Leptospire severity in animal hosts. In conclusion, rLipL21 can act as a vaccine capable of effectively and safely against the infection of five strains of Leptospira interrogans in Vietnam
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