Abstract
A Rare Case of Thyrotoxic Periodic Paralysis Caused by TSH-Secreting Pituitary Adenoma: Case Report and Review of the Literature
Highlights
Periodic quadriplegia presents with a transient quadriplegia attack, which lasts for several hours or for a few days
The low potassium type of periodic quadriplegia is frequently observed as thyrotoxic periodic paralysis (TPP) in Asian countries, including Japan [1,2], and is rare in Western countries [3,4]
Thyroid hormones can increase Na/K-ATPase activity in various tissues, including skeletal muscle, inducing an influx of potassium into the intracellular space [17,18,19]. These findings suggest that elevation of thyroid hormones appears be a central mechanism of TPP, regardless of the cause (e.g. Basedow’s disease or TSH-secreting pituitary adenoma)
Summary
A Rare Case of Thyrotoxic Periodic Paralysis Caused by TSH-Secreting Pituitary Adenoma: Case Report and Review of the Literature. Further examination showed that he had inappropriate TSH secretion and a pituitary tumor. He was suspected as having thyrotoxic periodic paralysis (TPP) due to TSH-secreting pituitary adenoma. Our case is rare and the 6th reported TPP case caused by TSH-secreting pituitary adenoma. Our results suggest that TPP is not caused by an autoimmune mechanism, but thyroid hormones instead. We review five other rare cases of TPP caused by TSHsecreting pituitary adenoma.
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