Abstract
Background: There are very few publications on synchronous presentation of dual malignancies in the literature. Occurrence of second malignancy in a patient with a known malignant tumor is not uncommon, though synchronous primary malignancies are unusual. Case Presentation: A 77-year-old man was diagnosed elsewhere as squamous cell carcinoma of lung came to our oncology department for further management. He underwent bone marrow evaluation with the suspicious of metastasis in view of pancytopenia. On bone marrow evaluation, found to have prominence of blasts more than 20%, which were CD34 positive and CD117 positive and. Conclusion: Here we describe an unusual rare combination of synchronous presentation of acute myeloid leukemia and squamous cell carcinoma of lung.
Highlights
IntroductionThere is an increase in incidence of second primary malignancy (SPM) in patients with known malignancy due to improvement in diagnostic techniques, changes in treatment modalities and an increasing number of elderly patients
Case Presentation: A 77-year-old man was diagnosed elsewhere as squamous cell carcinoma of lung came to our oncology department for further management
Here we describe an unusual rare combination of synchronous presentation of acute myeloid leukemia and squamous cell carcinoma of lung
Summary
There is an increase in incidence of second primary malignancy (SPM) in patients with known malignancy due to improvement in diagnostic techniques, changes in treatment modalities and an increasing number of elderly patients. Though occurrence of metachronous primary dual malignancies is not uncommon, synchronous dual malignancies are still unusual. The exact pathophysiology for Multiple Primary Malignancies (MPM) remains unknown. Chakrabarti et al [2] have reported twelve cases of MPM against a total of 1255 cases over a period of two years. Five cases were synchronous malignancies and seven cases were metachronous. Studies have reported that the relative risks of the second SPM range from 1.08 to 1.3 [3]. Treatment and outcome of synchronous dual malignancies is still sparse. We present a rare case of synchronous dual malignancies from our tertiary care centre
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