Abstract
Mesalazine is a commonly used first-line therapy to treat acute mild to moderate ulcerative colitis (UC). Myocarditis is a rare complication of inflammatory bowel disease. This is a case report of a 19-year-old female with myocarditis induced after commencing mesalazine for UC. She was admitted with pleuritic-type chest pain associated with severe dyspnoea and was hemodynamically unstable during admission. She had elevated troponin and N-terminal pro-B-type natriuretic peptide. Transthoracic echocardiogram (TTE) results suggested there was evidence of myocarditis with reduced ejection fraction, which was later confirmed by cardiac magnetic resonance imaging. There was a rapid improvement of cardiac status after stopping mesalazine within two weeks.
Highlights
Inflammatory bowel disease (IBD) is a disorder causing chronic inflammation of the gastrointestinal tract
Myocarditis is a rare complication of inflammatory bowel disease
This is a case report of a 19-year-old female with myocarditis induced after commencing mesalazine for ulcerative colitis (UC)
Summary
Inflammatory bowel disease (IBD) is a disorder causing chronic inflammation of the gastrointestinal tract. Based on the results of flexible sigmoidoscopy and biopsy, the diagnosis of moderate UC was established and a maximum dose of oral mesalazine 2.4 grams a day and a tapering dose of oral prednisolone (starting at 30 mg OD) were prescribed She responded well to treatment, reporting improved abdominal symptoms. There was an elevated cardiac troponin-T enzyme of 64 ng/ml (laboratory normal of
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