Abstract
Central precocious puberty (CPP) is defined as development of secondary sex characteristics in relation with activationof the HPG axis before the age of 8 years in girls and before the age of 9 years in boys. CPP is far less common inchildren before 3 years of age, particularly in females. Most girls with signs of puberty less than 3 years of age arediagnosed with premature thelarche (PT). Although CPP presenting with early breast development should be differentiatedfrom PT, there is no diagnostic method which would definitely differentiate these two conditions. We present idiopathicCPP before 3 years of age who presented with PT that rapidly progressed to CPP. Up to date, there are no predictiveclinical or laboratory tests that can identify the risk of progression to PP at time of onset. Therefore, all girls with PTshould be monitored clinically for accelerated pubertal progression.
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