Abstract
An attempt has been made to measure the frequency of mutations throughout the lifespan of human fibroblast strain MRC-5. A novel procedure has been used which involves staining individual cells for high levels of glucose-6-phosphate dehydrogenase. Evidence is presented that this phenotype is due to mutation. The frequency of variants was scored from passage 16 until the final phase of senescence (passage 60). There is an exponential increase of stained cells throughout this period. The results are in agreement with the general error theory, which proposes that aging is due to a breakdown in the fidelity of information transfer between macromolecules.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.