Abstract
An enzyme immunoassay for the quantification of-human Cu/Zn SOD in serum, urine and erythrocytes was developed applying monoclonal and polyclonal antibodies. The one-step assay is completed within 30 min and enables the detection of 0.3 μg Cu/Zn SOD per litre. A Cu/Zn SOD concentration of 46 ± 21.5 μg/1 and of 1 ± 0.6 μg/mmol creatinine was determined in the serum and the urine, respectively, of healthy individuals. A content of 15 ± 1.7 ng Cu/Zn SOD was found in 10 6erythrocytes. Patients with Down's syndrome exhibited a 3.8-fold, a 2-fold and a 1.6-fold higher concentration of Cu/Zn SOD in their serum, urine and erythrocytes.
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