Abstract
Upper airway problems and stress can cause sleep disorders. The present study was designed to evaluate the efficacy and safety of wild sage metabolites (WSM) for snoring treatment and alpha wave activation in healthy men and women. A total of 42 subjects compliant with inclusion criteria were randomly assigned to one of the two groups, viz. Group 1-WSM and Group 2-Placebo, using a simple randomization process. Consumption of WSM by healthy men and women resulted in the decrease of Pittsburgh Sleep Quality Index (PSQI) global score by 29%, improved assessment by their sleep mates, and increased alpha brain wave by 55%. In conclusion, medication with WSM resulted in significant reduced snoring, stress, and improved sleep quality after 30 days, with a good tolerance among subjects. No side effects or adverse events were reported during the study. Hence, WSM at 450 mg/day could be recommended as an effective agent for snoring treatment, improving the quality of sleep, and stress reduction.
Highlights
Upper airway problems can cause sleep disorders
Consumption of wild sage metabolites (WSM) by healthy men and women resulted in the decrease of Pittsburgh Sleep Quality Index (PSQI) global score by 29%, improved assessment by their sleep mates, and increased alpha brain wave by 55%
The present study aims to elucidate the efficacy of WSM in managing snoring, stress, and improving sleep in healthy adults
Summary
Upper airway problems can cause sleep disorders. An airway constriction that occurs because of relaxation of the soft tissue anatomy in the oropharyngeal region increases the speed of airflow during sleeping. Air that quickly passes through narrow passage results in loud sounds due to the vibrating unsupported tissues of the upper airway [1]. Surgeries, such as septorhinoplasty, that improve nasal patency have an important role in the treatment of snoring. Septorhinoplasty does not provide complete correction of snoring in conditions such as sagging of the soft palate and bulking of the soft palate-uvula tissue and/or the tongue [2]. Elimination of upper airway problems with correction of current hypotonia in the muscles of the soft palate is required in the treatment of snoring
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