Abstract
Objectives Although a number of studies have shown misoprostol's promise as a nonsurgical treatment for incomplete abortion, few have systematically examined treatment protocols. This study documents the effectiveness of 600 versus 1200 μg oral misoprostol for this indication. Methods From May 2002 to January 2003, 300 women with incomplete abortion were recruited at a large tertiary facility in Vietnam and randomized to either a single-dose (600 μg) or a repeated-dose (600 μg×2) regimen of oral misoprostol for the treatment of their condition. Results Misoprostol effectively evacuated the uterus for nearly all women (94.6%; n=279), with most reporting bleeding for 4 days (±2.3) and pain/cramps lasting 1 day (±1.0). Women indicated that the side effects were tolerable (96%) and that their experience was satisfactory (95%). Conclusions Oral misoprostol (600 or 1200 μg) offers a safe, effective and acceptable treatment for incomplete abortion. Larger studies to assess the advantages and disadvantages of misoprostol as compared with standard surgical care are needed to assess its role in postabortion care programs worldwide.
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