Abstract
Quiescence is a common character in stem cells. Low cellular activity in these cells may function to minimize the potential damaging effects of oxidative stress, reduce the number of cells needed for tissue replenishment, and as a consequence, perhaps occupy unique niches. Quiescent stem cells are found in many adult human tissues, the hematopoietic stem cells are paradigmatic, and more recently it appears that stem cell of the germ line in many animals display quiescence characters. Here we explore the diversity of quiescence phenotypes in primordial germ cells, leveraging the diverse mechanisms of germ cell formation to extract evolutionary significance to common processes.
Highlights
Quiescence is a common character in stem cells
The quiet space for primordial germ cells (PGCs) is distinct from the somatic rush, but varied for diverse animals
What appears to be an essential step for success of germ line formation is independent of specific transcriptional and translational events that we might normally associate with making a new cell type
Summary
Quiescence is a common character in stem cells. Low cellular activity in these cells may function to minimize the potential damaging effects of oxidative stress, reduce the number of cells needed for tissue replenishment, and as a consequence, perhaps occupy unique niches. PIE-1 prevents CTD Ser 2 phosphorylation through interaction with CycT, the regulatory subunit of the cdk9, kinase domain of P-TEFb. P-TEFb seems to be a common regulatory target for the repression of mRNA transcription during germ cell specification both in Drosophila and C. elegans, yet Pgc and PIE-1, the mechanisms of repression, are unrelated.
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