Abstract
Aboriginal secretors synthesize greater concentrations of H, A and Le<sup>a</sup> antigens than do Caucasians but, in A<sub>x</sub> secretors, most H determinants are converted to A. Since Aboriginal secretors have concentrations of Le<sup>a</sup> in the saliva similar to those of Caucasian non-secretors, it is suggested that the red cell phenotype, Le(a+b+), observed in over 10% of Aborigines, is due to the high concentration of Le<sup>a</sup> which is not converted to Le<sup>b</sup>. Aboriginal <i>A<sub>1</sub></i>secretors have significantly greater concentrations of Le<sup>a</sup> in their salivas than have·secretors. This observation has led to the proposal that, in the genetically-controlled biosynthetic pathways leading to the production of Lewis and ABH antigens in saliva, the genes add their specificities in the order <i>H, A </i>(and/or presumably B), <i>Le.</i>
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