Abstract
A quantitative analysis was made of the antagonism by compound WV 0062, N-(2-chloroethyl)- N-[2-(4-chloro-2-isopropyl-5- methylphenoxy)-1-methylethyl] ethylamine hydrochloride, of the responses of some isolated smooth muscle preparations to agonist drugs. The antagonism of noradrenaline or acetylcholine-induced contractions of smooth muscle had the characteristics of non-competitive blockade; the blockade was insurmountable and seemed to be very long-lasting. WV 0062 contracted the guinea-pig ileum and the rat stomach strip. It is concluded that WV 0062 is a very potent compound (pA h approximately 10) which exhibits the non-competitive blocking action and the non-specificity associated with other haloalkylamines and is therefore unlike its analogue, thymoxamine, which is a relatively specific competitive blocking agent at a-receptors.
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