Abstract
Background Organ perfusion can be quantified by direct calibration of relative perfusion images using absolute blood volume (ml/100g) [1]. It is well known that for an intravascular gadolinium-based T1 shortening contrast agent, the parenchymal T1 change reflects tissue blood volume [2].However, to accurately quantify blood flow from blood volume, we must describe the compartmentalization effects of intrato extra-vascular water exchange [2,3].
Highlights
Organ perfusion can be quantified by direct calibration of relative perfusion images using absolute blood volume [1]
Over-estimation of MBV may be caused by extravasation of MS-325, and to a lesser extent by T2 bias on the T1 measurements with the steady-state free precession MOLLI sequence
The measured MBV was 40% of total myocardial volume, or 28 ml/100g, a value that overestimates those quoted in the literature [5]
Summary
Absolute myocardial perfusion MR imaging (ml/min/ 100g tissue) has the potential to timely diagnose and reduce patient mortality from coronary artery disease. Myocardial blood volume (MBV) was calculated from the baseline to post-contrast change in T1 in the blood pool and myocardium
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