Abstract
Cognitive function is critical for successful prolonged performance in eSports. This double-blind placebo-controlled study examined the effect of an inositol-enhanced arginine silicate oral supplement on cognitive performance and energy in eSports athletes. Sixty healthy men and women who spent 5 or more hours a week playing video games were randomly assigned to take supplement or placebo for 7 days. On day 1 and 7, before and 15 min after dosing, subjects completed the Trail Making Test (TMT), Parts A and B; Stroop Test; and Profile of Mood States (POMS) questionnaire, and then played a video game for 60 min. Immediately after, cognitive tests were repeated. Self-reported energy levels increased, anger decreased, and TMT-B test errors decreased in the supplement group compared to placebo (p < 0.05). Fatigue, TMT-B time, and TMT B-A score improved in the supplement group compared to baseline (p < 0.05). After 60 min of gaming, supplementation decreased Stroop Test errors and TMT-A time (p < 0.05). Adverse events were minimal and not different between groups. These data appear to support the use of the studies product (nooLVL®) in eSports gamers looking to improve their accuracy, decision making, and reaction time during gaming.
Highlights
Inositolstabilized arginine silicate is an active nutrition ingredient which has been shown to significantly enhance blood levels of arginine and silicon, while enhancing nitric oxide (NO) levels [1]
The product utilized in this study is a formulation of arginine silicate that has been optimized for cognitive impact through the addition of increased inositol
In addition to its physiological functions in the body, inositol aids in the manufacturing of arginine silicate as it allows for the 1:1 binding of arginine to silicon and prevents the polymerization of silicon [2]
Summary
Inositolstabilized arginine silicate is an active nutrition ingredient (as ASI-Nitrosigine® ) which has been shown to significantly enhance blood levels of arginine and silicon, while enhancing nitric oxide (NO) levels [1]. The product utilized in this study is a formulation of arginine silicate that has been optimized for cognitive impact through the addition of increased inositol. Proton magnetic resonance studies show that oral administration increases inositol levels in the brain. In addition to its physiological functions in the body, inositol aids in the manufacturing of arginine silicate as it allows for the 1:1 binding of arginine to silicon and prevents the polymerization of silicon [2]. The product studied is a novel dietary supplement composed of a specific ratio of inositol-stabilized arginine silicate and inositol that differs from ASI. NO is best known for its role in vasodilation which leads to increased blood flow and Nutrients 2019, 11, 2326; doi:10.3390/nu11102326 www.mdpi.com/journal/nutrients
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