Abstract
Aim: The aim of this study was to compare the effect of Myo-inositol plus diet and diet alone in patients with gestational diabetes mellitus. Materials and methods: A Randomized Prospective study was carried out in Gestational Diabetes Mellitus patients to evaluate the efficacy of Myoinositol+diet vs Diet alone in the department of Gynaecology, Durgabhai Deshmukh Hospital, a 300 bedded multispecialty hospital from September 2018-April 2019.OGTT test was conducted to measure blood glucose levels. Results: Among the total number of patients (60), Myoinositol + diet is given in 50% and diet is given in 50% of the patients. Among 30 patients on diet, 19 patients couldn’t control rising blood glucose levels and were prescribed insulin for reduction of blood glucose levels. Among 30 patients on myoinositol+ diet, 4 patients couldn’t control 1 hr blood glucose levels and were prescribed insulin to control blood glucose levels. Conclusion: This study showed that Myoinositol + diet is effective than only diet with respect to decrease in blood glucose levels and safety among patients with Gestational Diabetes Mellitus. Therefore, we conclude that myoinositol + diet is safe and effective in reducing fasting and 2hr blood glucose levels.
Highlights
Gestational Diabetes Mellitus (GDM) is the common medical complication characterized by increased insulin resistance and by increased risk for adverse pregnancy outcomes affecting both the mother and the fetus [1]
Among 30 patients on myoinositol+ diet, 4 patients couldn’t control 1 hr blood glucose levels and were prescribed insulin to control blood glucose levels.In patients with Gestational Diabetes Mellitus when compared to other groups, age group between 25-30yrs(37%) are found to be more than 20-25yrs(31.5%) & 3035yrs(31.5%).In patients with Gestational Diabetes Mellitus when compared to other groups, patients weighing between 41-50kgs(32%) are found to be more and 71-80kgs(16%) are found to be less.In patients with Gestational Diabetes Mellitus when compared to other groups, BMI between 18.5-25(normal BMI)(52.6%) were found to be more prone to develop Gestational Diabetes Mellitus
GSC Biological and Pharmaceutical Sciences, 2021, 14(03), 197–201 Figure 2 Incidence of GDM based on age groups Figure 3 incidence of GDM based on weight Figure 4 incidence of GDM based on BMI 199
Summary
Gestational Diabetes Mellitus (GDM) is the common medical complication characterized by increased insulin resistance and by increased risk for adverse pregnancy outcomes affecting both the mother and the fetus [1]. Gestational Diabetes mellitus is said to be any degree of glucose intolerance with an onset or first recognized during pregnancy [2]. It does increase the risk of preeclampsia and requiring a Caesarean section [3]. Infants of mothers with gestational diabetes mellitus can grow disproportionately large for their gestational age [5]. This in turn increases the likelihood of traumatic birth or shoulder dystocia leading to birth injuries such as bone fracture or nerve palsy. The diagnosis of GDM is usually made using an Oral Glucose Tolerance Test (OGTT) between 24 to 28 weeks gestation [9]
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