Abstract
BackgroundHousehold contacts of cholera patients are at a 100 times higher risk of developing cholera than the general population. The objective of this study was to examine the incidence of V. cholerae infections among household contacts of cholera patients in a rural setting in Bangladesh, to identify risk factors for V. cholerae infections among this population, and to investigate transmission pathways of V. cholerae using multilocus variable-number tandem-repeat analysis (MLVA).Methodology/Principal findingsStool from household contacts, source water and stored water samples were collected from cholera patient households on Day 1, 3, 5, and 7 after the presentation of the index patient at a health facility. Two hundred thirty clinical and water V. cholerae isolates were analyzed by MLVA. Thirty seven percent of households had at least one household contact with a V. cholerae infection. Thirteen percent of households had V. cholerae in their water source, and 27% had V. cholerae in stored household drinking water. Household contacts with V. cholerae in their water source had a significantly higher odds of symptomatic cholera (Odds Ratio (OR): 5.49, 95% Confidence Interval (CI): 1.07, 28.08). Contacts consuming street vended food had a significantly higher odds of a V. cholerae infection (OR: 9.45, 95% CI: 2.14, 41.72). Older age was significantly associated with a lower odds of a V. cholerae infection (OR: 0.96, 95% CI: 0.93, 0.99). Households with both water and clinical V. cholerae-positive samples all had isolates that were closely related by MLVA.Conclusions/SignificanceThese findings emphasize the need for interventions targeting water treatment and food hygiene to reduce V. cholerae infections.
Highlights
The World Health Organization estimates that there are 95,000 cholera deaths per year with 2.9 million cases worldwide [1]
Household members of cholera patients are at a 100 times higher risk of developing cholera infections than the general population
In this study we investigated the rate of cholera transmission within cholera patient households, identified risk factors for household cholera transmission, and performed genetic characterization of cholera strains collected
Summary
The World Health Organization estimates that there are 95,000 cholera deaths per year with 2.9 million cases worldwide [1]. Studies have identified risk factors for becoming infected with cholera such as age [2], drinking street-vended water [3], placing ones hands into stored household water [4], bathing in a river [4, 5], eating leftover food [6], eating food prepared by a recently ill food handler [7], not washing hands with soap before eating food [8], and being a first degree relative of a cholera case [9] These findings indicate that water and food borne contamination are the main transmission routes for V. cholerae infection. The objective of this study was to examine the incidence of V. cholerae infections among household contacts of cholera patients in a rural setting in Bangladesh, to identify risk factors for V. cholerae infections among this population, and to investigate transmission pathways of V. cholerae using multilocus variable-number tandemrepeat analysis (MLVA)
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