Abstract
BackgroundBody composition and obesity is one of the major health related risk factors leading to increased metabolic mortality and morbidity. The Association of genetic polymorphism with obesity and body composition is one way to assess the health status of a given population. In Indian region of east and north east, population-based studies have been conducted to assess the relation of body composition and obesity with gene polymorphism known to be associated with obesity and cardiovascular health and disease. MethodsThe current study consisted of different ethnic groups of Eastern and North Eastern part of India. A total of 225 randomly selected apparently healthy unrelated (free from any major diseases) adult individuals of 12 Ethnic groups were selected for the present study. Kurmi, Bhumij and Bouri population of Purulia District, and Bengali population of Kolkata, West Bengal, Meitei population of Manipur, Kolui, Riang, Rupini, Chakma and Tripuri of Tripura, Santal and Sabar population of Jharkhand, India were incorporated in the present study. FTO, ACE3, PSD3 and A604G genotyping by Restriction Fragment length Polymorphism (RFLP) was performed to study specific Single Nucleotide Polymorphism (SNP) among the population. Anthropometric and socio demographic data were collected from all the subjects as per standard procedure. Overweight and obese categories for BMI classification was determined using classifications based on BMI, WC, WHR, WSR and BF percentage. ResultsThe genetic polymorphism studied showed no significant relation among any of the 4 gene polymorphism with body composition variables. Smaller insignificant fraction of polymorphism for ACE, FTO gene was observed in population 3. PSD3 and A604G and polymorphism was not observed in any of the population studied. ConclusionComparison of the results from anthropometric, physiological, metabolic data on the basis of body composition and gene polymorphism indicated that the studied population of twelve ethnic groups might not be susceptible to ACE, FTO, PSD3 and A604G associated obesity related disease.
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