Abstract
1.1.Aim:Peyronie’s disease is a disorder of the penile tunica albuginea characterized by development of a fibrotic plaque. This is a preliminary study that looking for the effects and probable side effects of mitomycin-C (as potential anti-fibroblast and anti-collagen properties) on normal Tunica albuginea. 1.2.Methods: Ten rats were allocated to three groups. Group 1(two rats as control group) received saline injection; in groups 2(six rats) and 3(two rats), 0.01 mg mitomycin-c were injected in tunica albuginea layer. The specimens were achieved after sacrificing of rats after 1 week in group 1 and 2 and 4 weeks in group 3. All tissue sections were stained by Haematoxylin-Eosin and Masson trichrome. The staining density reflects the collagen content of tissues was quantified by quantitative image analysis (QIA). Collagen density was determined one week following the injection in groups 1 and 2; after 4 weeks in group 3. 1.3.Results:Although the results were better after injection, there was no significant difference between the groups. We did not have any local complications. 1.4.Conclusion:Although collagen density was reduced after injection, there was no significant difference between the groups. Further investigations are warranted to confirm our study and evaluate the effect of mitomycin-C on pathologic penile tissue (PD).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
