Abstract
Background The Leksell Gamma Knife® has been used for several decades as a relatively non-invasive, highly effective and precise therapeutic tool for brain disorders ranging from tumors to vascular malformations. It has a very benign side effect profile. To date many animal hydrocephalus models have been surgically or chemically invasive. Our exploratory model uses gamma knife to induce a lesion with the aim of increasing CSF outflow resistance at the cerebral aqueduct.
Highlights
The Leksell Gamma Knife® has been used for several decades as a relatively non-invasive, highly effective and precise therapeutic tool for brain disorders ranging from tumors to vascular malformations
Our exploratory model uses gamma knife to induce a lesion with the aim of increasing CSF outflow resistance at the cerebral aqueduct
Subependymal fluid-attenuated inversion-recovery MRI (FLAIR) hyperintensity lining the lateral ventricles was present at 4 weeks
Summary
The Leksell Gamma Knife® has been used for several decades as a relatively non-invasive, highly effective and precise therapeutic tool for brain disorders ranging from tumors to vascular malformations. It has a very benign side effect profile. To date many animal hydrocephalus models have been surgically or chemically invasive. Our exploratory model uses gamma knife to induce a lesion with the aim of increasing CSF outflow resistance at the cerebral aqueduct
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